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It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250 nM
Formula: C16H18N4O2
AG-120 is well tolerated to date (10/2015) and MTD was not reached
Hammitzsch A
Pinometostat
ML228 - HIF Pathway Activator. CAS# 1357171-62-0 0161 It reduces recovery time inML228, CAS No. 1357171 62 0, is a hypoxia inducible factor (HIF) pathway activator with an EC50 at ~1. 23 M in HRE gene reporter assay and ~1. 4 M in HIF 1 nuclear translocation assay. It does not inhibit the proteasome, but activates HIF stabilization and nuclear translocation, and induces expression of a HIF specific downstream gene (VEGF). It has no apparent toxicity below 30 M and appeared to be an iron chelator, independently of PHD. HIFs are
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